Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis.
Identifieur interne : 007847 ( Main/Exploration ); précédent : 007846; suivant : 007848Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis.
Auteurs : Masabumi Shibuya [Japon] ; Lena Claesson-WelshSource :
- Experimental cell research [ 0014-4827 ] ; 2006.
Descripteurs français
- KwdFr :
- Animaux, Division cellulaire, Développement embryonnaire (physiologie), Endothélium vasculaire (cytologie), Endothélium vasculaire (physiologie), Humains, Néovascularisation pathologique (physiopathologie), Néovascularisation physiologique (physiologie), Récepteur-1 au facteur croissance endothéliale vasculaire (génétique), Récepteur-1 au facteur croissance endothéliale vasculaire (physiologie), Récepteur-2 au facteur croissance endothéliale vasculaire (génétique), Récepteur-2 au facteur croissance endothéliale vasculaire (physiologie), Système lymphatique (physiologie), Transduction du signal (physiologie), Vertébrés, Vieillissement (physiologie).
- MESH :
- cytologie : Endothélium vasculaire.
- génétique : Récepteur-1 au facteur croissance endothéliale vasculaire, Récepteur-2 au facteur croissance endothéliale vasculaire.
- physiologie : Développement embryonnaire, Endothélium vasculaire, Néovascularisation physiologique, Récepteur-1 au facteur croissance endothéliale vasculaire, Récepteur-2 au facteur croissance endothéliale vasculaire, Système lymphatique, Transduction du signal, Vieillissement.
- physiopathologie : Néovascularisation pathologique.
- Animaux, Division cellulaire, Humains, Vertébrés.
English descriptors
- KwdEn :
- Aging (physiology), Animals, Cell Division, Embryonic Development (physiology), Endothelium, Vascular (cytology), Endothelium, Vascular (physiology), Humans, Lymphatic System (physiology), Neovascularization, Pathologic (physiopathology), Neovascularization, Physiologic (physiology), Signal Transduction (physiology), Vascular Endothelial Growth Factor Receptor-1 (genetics), Vascular Endothelial Growth Factor Receptor-1 (physiology), Vascular Endothelial Growth Factor Receptor-2 (genetics), Vascular Endothelial Growth Factor Receptor-2 (physiology), Vertebrates.
- MESH :
- chemical , genetics : Vascular Endothelial Growth Factor Receptor-1, Vascular Endothelial Growth Factor Receptor-2.
- cytology : Endothelium, Vascular.
- physiology : Aging, Embryonic Development, Endothelium, Vascular, Lymphatic System, Neovascularization, Physiologic, Signal Transduction, Vascular Endothelial Growth Factor Receptor-1, Vascular Endothelial Growth Factor Receptor-2.
- physiopathology : Neovascularization, Pathologic.
- Animals, Cell Division, Humans, Vertebrates.
Abstract
The VEGF/VPF (vascular endothelial growth factor/vascular permeability factor) ligands and receptors are crucial regulators of vasculogenesis, angiogenesis, lymphangiogenesis and vascular permeability in vertebrates. VEGF-A, the prototype VEGF ligand, binds and activates two tyrosine kinase receptors: VEGFR1 (Flt-1) and VEGFR2 (KDR/Flk-1). VEGFR1, which occurs in transmembrane and soluble forms, negatively regulates vasculogenesis and angiogenesis during early embryogenesis, but it also acts as a positive regulator of angiogenesis and inflammatory responses, playing a role in several human diseases such as rheumatoid arthritis and cancer. The soluble VEGFR1 is overexpressed in placenta in preeclampsia patients. VEGFR2 has critical functions in physiological and pathological angiogenesis through distinct signal transduction pathways regulating proliferation and migration of endothelial cells. VEGFR3, a receptor for the lymphatic growth factors VEGF-C and VEGF-D, but not for VEGF-A, regulates vascular and lymphatic endothelial cell function during embryogenesis. Loss-of-function variants of VEGFR3 have been identified in lymphedema. Formation of tumor lymphatics may be stimulated by tumor-produced VEGF-C, allowing increased spread of tumor metastases through the lymphatics. Mapping the signaling system of these important receptors may provide the knowledge necessary to suppress specific signaling pathways in major human diseases.
DOI: 10.1016/j.yexcr.2005.11.012
PubMed: 16336962
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 003B32
- to stream PubMed, to step Curation: 003B32
- to stream PubMed, to step Checkpoint: 003B32
- to stream Ncbi, to step Merge: 002054
- to stream Ncbi, to step Curation: 002054
- to stream Ncbi, to step Checkpoint: 002054
- to stream Main, to step Merge: 007A17
- to stream Main, to step Curation: 007847
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis.</title><author><name sortKey="Shibuya, Masabumi" sort="Shibuya, Masabumi" uniqKey="Shibuya M" first="Masabumi" last="Shibuya">Masabumi Shibuya</name><affiliation wicri:level="4"><nlm:affiliation>University of Tokyo, Institute of Medical Science, 4-6-1 Shirokane-dai, Tokyo 108-8639, Japan. shibuya@ims.u-tokyo.ac.jp</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>University of Tokyo, Institute of Medical Science, 4-6-1 Shirokane-dai, Tokyo 108-8639</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region><settlement type="city">Tokyo</settlement></placeName><orgName type="university">Université de Tokyo</orgName></affiliation></author><author><name sortKey="Claesson Welsh, Lena" sort="Claesson Welsh, Lena" uniqKey="Claesson Welsh L" first="Lena" last="Claesson-Welsh">Lena Claesson-Welsh</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="RBID">pubmed:16336962</idno><idno type="pmid">16336962</idno><idno type="doi">10.1016/j.yexcr.2005.11.012</idno><idno type="wicri:Area/PubMed/Corpus">003B32</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003B32</idno><idno type="wicri:Area/PubMed/Curation">003B32</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003B32</idno><idno type="wicri:Area/PubMed/Checkpoint">003B32</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003B32</idno><idno type="wicri:Area/Ncbi/Merge">002054</idno><idno type="wicri:Area/Ncbi/Curation">002054</idno><idno type="wicri:Area/Ncbi/Checkpoint">002054</idno><idno type="wicri:doubleKey">0014-4827:2006:Shibuya M:signal:transduction:by</idno><idno type="wicri:Area/Main/Merge">007A17</idno><idno type="wicri:Area/Main/Curation">007847</idno><idno type="wicri:Area/Main/Exploration">007847</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis.</title><author><name sortKey="Shibuya, Masabumi" sort="Shibuya, Masabumi" uniqKey="Shibuya M" first="Masabumi" last="Shibuya">Masabumi Shibuya</name><affiliation wicri:level="4"><nlm:affiliation>University of Tokyo, Institute of Medical Science, 4-6-1 Shirokane-dai, Tokyo 108-8639, Japan. shibuya@ims.u-tokyo.ac.jp</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>University of Tokyo, Institute of Medical Science, 4-6-1 Shirokane-dai, Tokyo 108-8639</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region><settlement type="city">Tokyo</settlement></placeName><orgName type="university">Université de Tokyo</orgName></affiliation></author><author><name sortKey="Claesson Welsh, Lena" sort="Claesson Welsh, Lena" uniqKey="Claesson Welsh L" first="Lena" last="Claesson-Welsh">Lena Claesson-Welsh</name></author></analytic><series><title level="j">Experimental cell research</title><idno type="ISSN">0014-4827</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aging (physiology)</term><term>Animals</term><term>Cell Division</term><term>Embryonic Development (physiology)</term><term>Endothelium, Vascular (cytology)</term><term>Endothelium, Vascular (physiology)</term><term>Humans</term><term>Lymphatic System (physiology)</term><term>Neovascularization, Pathologic (physiopathology)</term><term>Neovascularization, Physiologic (physiology)</term><term>Signal Transduction (physiology)</term><term>Vascular Endothelial Growth Factor Receptor-1 (genetics)</term><term>Vascular Endothelial Growth Factor Receptor-1 (physiology)</term><term>Vascular Endothelial Growth Factor Receptor-2 (genetics)</term><term>Vascular Endothelial Growth Factor Receptor-2 (physiology)</term><term>Vertebrates</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Division cellulaire</term><term>Développement embryonnaire (physiologie)</term><term>Endothélium vasculaire (cytologie)</term><term>Endothélium vasculaire (physiologie)</term><term>Humains</term><term>Néovascularisation pathologique (physiopathologie)</term><term>Néovascularisation physiologique (physiologie)</term><term>Récepteur-1 au facteur croissance endothéliale vasculaire (génétique)</term><term>Récepteur-1 au facteur croissance endothéliale vasculaire (physiologie)</term><term>Récepteur-2 au facteur croissance endothéliale vasculaire (génétique)</term><term>Récepteur-2 au facteur croissance endothéliale vasculaire (physiologie)</term><term>Système lymphatique (physiologie)</term><term>Transduction du signal (physiologie)</term><term>Vertébrés</term><term>Vieillissement (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Vascular Endothelial Growth Factor Receptor-1</term><term>Vascular Endothelial Growth Factor Receptor-2</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Endothélium vasculaire</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Endothelium, Vascular</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Récepteur-1 au facteur croissance endothéliale vasculaire</term><term>Récepteur-2 au facteur croissance endothéliale vasculaire</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Développement embryonnaire</term><term>Endothélium vasculaire</term><term>Néovascularisation physiologique</term><term>Récepteur-1 au facteur croissance endothéliale vasculaire</term><term>Récepteur-2 au facteur croissance endothéliale vasculaire</term><term>Système lymphatique</term><term>Transduction du signal</term><term>Vieillissement</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Aging</term><term>Embryonic Development</term><term>Endothelium, Vascular</term><term>Lymphatic System</term><term>Neovascularization, Physiologic</term><term>Signal Transduction</term><term>Vascular Endothelial Growth Factor Receptor-1</term><term>Vascular Endothelial Growth Factor Receptor-2</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Néovascularisation pathologique</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Neovascularization, Pathologic</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Division</term><term>Humans</term><term>Vertebrates</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Division cellulaire</term><term>Humains</term><term>Vertébrés</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The VEGF/VPF (vascular endothelial growth factor/vascular permeability factor) ligands and receptors are crucial regulators of vasculogenesis, angiogenesis, lymphangiogenesis and vascular permeability in vertebrates. VEGF-A, the prototype VEGF ligand, binds and activates two tyrosine kinase receptors: VEGFR1 (Flt-1) and VEGFR2 (KDR/Flk-1). VEGFR1, which occurs in transmembrane and soluble forms, negatively regulates vasculogenesis and angiogenesis during early embryogenesis, but it also acts as a positive regulator of angiogenesis and inflammatory responses, playing a role in several human diseases such as rheumatoid arthritis and cancer. The soluble VEGFR1 is overexpressed in placenta in preeclampsia patients. VEGFR2 has critical functions in physiological and pathological angiogenesis through distinct signal transduction pathways regulating proliferation and migration of endothelial cells. VEGFR3, a receptor for the lymphatic growth factors VEGF-C and VEGF-D, but not for VEGF-A, regulates vascular and lymphatic endothelial cell function during embryogenesis. Loss-of-function variants of VEGFR3 have been identified in lymphedema. Formation of tumor lymphatics may be stimulated by tumor-produced VEGF-C, allowing increased spread of tumor metastases through the lymphatics. Mapping the signaling system of these important receptors may provide the knowledge necessary to suppress specific signaling pathways in major human diseases.</div></front></TEI><affiliations><list><country><li>Japon</li></country><region><li>Région de Kantō</li></region><settlement><li>Tokyo</li></settlement><orgName><li>Université de Tokyo</li></orgName></list><tree><noCountry><name sortKey="Claesson Welsh, Lena" sort="Claesson Welsh, Lena" uniqKey="Claesson Welsh L" first="Lena" last="Claesson-Welsh">Lena Claesson-Welsh</name></noCountry><country name="Japon"><region name="Région de Kantō"><name sortKey="Shibuya, Masabumi" sort="Shibuya, Masabumi" uniqKey="Shibuya M" first="Masabumi" last="Shibuya">Masabumi Shibuya</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 007847 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 007847 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:16336962
|texte= Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:16336962" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |